HPE ProLiant DL380 Gen10 Silver 4310 2.1G -R Server

HPE ProLiant DL380 Gen10 Silver 4310 2.1G -R Server

 DL380 Gen10 Server

HPE ProLiant DL380 Gen10 Silver 4310 2.1G -R Server , Adaptable for diverse workloads and environments,

DL380 Gen10 Plus (2U) server, configured with an Intel Xeon Silver 4310 (2.1 GHz)—

perfect for understanding its capabilities, specs, and use cases:

HPE DL380 gen10 server front of system

Designed for data center standard High-Performance Computing applications,

the HPE ProLiant DL380 Gen10 supports dual 1st or 2nd Generation Intel Xeon Scalable Processors and a total of 24x DIMM slots evenly divided between each CPU socket.

This system supports up to 12x LFF or 24x SFF drive bays compatible with SAS, SATA, and NVMe drive formats.

System expansion is achieved through 6x PCIe 3.0 x8 slots and 2x PCIe 3.0 x16 slots.

Performance

This system can be outfitted with one or two 1st or 2nd Generation Intel Xeon Scalable Processors.

CPUs with between 4x and 28x Physical Cores, per socket, can be installed.

Cooling is provided by a bank of four fans for a single processor deployment, six fans for dual processors,

and six high-performance fans are recommended when the system is outfitted with a full complement of hard drives, and in other specific configurations.

Memory

DL380 Each processor supports six memory channels, and with 12 slots per socket,

can be outfitted with two memory modules per channel.

All 24x DIMM slots are active when both processors are installed.

Depending on CPU, memory modules, and configuration, a maximum of either 3TB or 6TB of memory is supported.

Compatible memory modules on this system include unbuffered (UDIMM), registered (RDIMM),

load-reduced (LRDIMM), NVMe (NVDIMM) modules,

and intel Optane Persisten memory modules (PMem).

NVDIMMs are only compatible with first generation Intel Xeon Scalable processors,

while PMem modules are only supported using 2nd generation CPUs.

Mixing memory modules of different types is not supported.

The 3TB memory configuration uses 128GB DDR4 modules while the 6TB uses a HPE 512GB 2666 Persistent Memory Kit.

Storage

The HPE DL380 Gen10 is highly adaptable and flexible,

supporting up to 190TB using 12x LFF drives in front along with an optional mid-plane HD carrier that supports 4 LFF drives internally and sits above the CPUs and memory modules.

A number of optional rear mounted drive cage options support additional SFF or LFF hard drives.

Several chassis configurations are available depending on your workload needs.

• 8 LFF drive chassis with Universal Media Bay
• 12 LFF drive chassis + optional 4 LFF mid-plane or 3 LFF + 2 SFF rear mounted drives
• 24 SFF drive chassis + optional 6 SFF rear-mounted drives
• 8 SFF drive chassis with Universal Media Bay, + 2 optional front mounted SFF or NVMe drives
• 20 SFF NVMe drive chassis with partial population of box1 on the front of the system

Expansion

The HPE DL380

There are a maximum of eight PCIe 3.0 expansion slots on the ProLiant DL380 Gen10 server depending on choice of risers and optional drive cages.

For all eight expansion slots to be active requires a second CPU and two optional risers.

The system has 4 x1GbEports, and a choice of HPE FlexibleLOM with the ability to choose network bandwidths from 1GbE to 40GbE or fabric with a suitable PCIe card.

For high performance computing and complex animation,

the system will support up to five single-wide or three double-wide GPUs.

Additional expansion cards can significantly increase I/O, graphics support,

high performance computing, or add additional storage.

Summary

The HPE ProLiant DL380 Gen10 Server supports dual 1st or 2nd Generation Intel Xeon Scalable Processors with each CPU socket supporting 12x DIMM slots for a total of 24x DIMM slots on the system board.

Depending on configuration, the front of the chassis will support 12x Large Form Factor or 24x Small Form Factor drive bays

with options for mid-plane and rear drive cages to augment up-front storage.

The system also supports multiple GPUs for compute acceleration or to enhance graphics processing.

Highlights & Insights

• Versatile & Scalable:

• Ideal for virtualization, databases, container workloads, or hybrid cloud deployments thanks to its dual CPU capability,

• high memory capacity, and fast PCIe Gen4 slots.

• Modern Connectivity:

• Native 10 GbE and NVMe RAID options make it performance-ready for demanding I/O-centric applications.

• Enterprise-grade Management:

• iLO 5 and HPE InfoSight support empower remote diagnostics,

• automated issue resolution, and efficient lifecycle handling.

CPU & Platform

• Processor: Intel Xeon Silver 4310

  • 12 cores, up to 24 threads, base clock 2.1 GHz,

  • boost to 3.3 GHz, 18 MB L3 cache, TDP around 120 W.

• Platform: Intel C621A chipset, supporting dual-processor setups.

Memory

• Installed: 1 × 32 GB DDR4 RDIMM (HPE SmartMemory)

• Slots: 32 DIMM slots total

• Max Capacity: Up to ~2 TB (RDIMM), higher with LRDIMM or Intel Optane persistent memory.

Storage & RAID

• Supports up to 8 SFF (2.5″) hot-swappable drives.

• RAID handled by HPE MR416i-p (Gen10 Plus) controller with 4 GB cache,

• supporting NVMe/SAS/SATA, and RAID levels 0,1,5,6,10,50,60.

Networking & Remote Management

• LAN: Dual 10 GbE ports via Broadcom BCM57412 (OCP 3.0 mezzanine)

• Management: HPE iLO 5 (Integrated Lights-Out) for remote server management.

Expansion & I/O

• PCIe Gen4 Slots: Three expansion slots configurable as x8/x16/x8.

• Ports: Up to 5 × USB 3.0 ports, VGA, iLO service port, plus networking ports.

Power & Cooling

• Standard power supply: single 800 W Flex Slot Platinum hot-plug

•  with optional redundancy.

• Includes 6 performance fans for optimized airflow.

Security & Software

• Offers firmware-level security, secure boot, root-of-trust features, lifecycle protection.

• Compatible OSes include various Windows Server editions,

• VMware vSphere,

• RHEL, SLES, Ubuntu,

• and Oracle Linux